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Left-handed DNA-PAINT for improved superresolution imaging in the nucleus.

Geertsema, H.; Aimola, G.; Fabricius, V.; Fuerste, J. P.; Kaufer, B.; Ewers, H.

2020-03-29 biophysics
10.1101/2020.03.28.010553 bioRxiv
Show abstract

DNA point accumulation in nanoscale topography (DNA-PAINT) advances super-resolution microscopy with superior resolution and multiplexing capabilities. However, cellular DNA may interfere with this single-molecule localization technique based on DNA-DNA hybridization. Here, we introduce left-handed DNA (L-DNA) oligomers that do not hybridize to naturally present R-DNA and demonstrate that L-DNA PAINT has the same specificity and multiplexing capability as R-DNA PAINT, but greatly improves specific visualization of nuclear target molecules.

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