A Self-Immobilizing NIR Probe for Non-invasive Imaging of Senescence
Liu, J.; Ma, X.; Cui, C.; Wang, Y.; Deenik, P. R.; Cui, L.
Show abstract
Cellular senescence, a process that arrests the cell cycle, is a cellular stress response to various stimuli and is implicated in aging and age-related diseases. However, the understanding of senescence in living organisms is insufficient, largely due to the scarcity of sensitive tools for the detection of cellular senescence in vivo. Herein, we describe the development of a self-immobilizing near-infrared (NIR) probe that can be activated by senescence-associated {beta}- Galactosidase (SA-{beta}-Gal), a widely accepted senescence marker. The NIR fluorophore is turned on in the presence of SA-{beta}-Gal, and the self-immobilizing group, based on quinone methide chemistry, retains the fluorescence signal to the site of activation. This strategy significantly improves the sensitivity of the probe from the one we developed before. We demonstrate the non-invasive imaging of drug-induced senescence in mice models.
Matching journals
The top 16 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Responsive fluorophore aggregation provides spectral contrast for fluorescence lifetime imaging 93%
- Laccase-mediated catalyzed fluorescent reporter deposition for live cell imaging 92%
- Rational Design of Self-assembling Artificial Proteins Utilizing a Micelle-Assisted Protein Labeling Technology (MAPLabTech): Testing the Scope 90%
Similar papers in this journal
- Artemisinin-Conjugated Phototheranostic Probe for Golgi-Targeted H2O2 Detection and Side Effect Attenuation 95%
- Alendronate Conjugate for Targeted Delivery to Bone-Forming Prostate Cancer 90%
- A Facile and Rapid Route to Self-Digitization of Samples into a High Density Microwell Array for Digital Bioassays 89%
Similar papers in this journal
- Molecular Tuning of Styryl Dyes Leads to Versatile and Efficient Plasma Membrane Probes for Cell and Tissue Imaging 94%
- A Dual Function Antibody Conjugate Enabled Photoimmunotherapy Complements Fluorescence and Photoacoustic Imaging of Head and Neck Cancer Spheroids 93%
- The effect of the size of gold nanoparticle contrast agents on CT imaging of the gastrointestinal tract and inflammatory bowel disease 90%
Similar papers in this journal
- Size-tunable ICG-based contrast agent platform for targeted near-infrared photoacoustic imaging 95%
- Bridging Light and Sound: a Spironaphtopyran-Rhodamine Dyad with High-Contrast Photoswitching Between Fluorescence and Photoacoustic Signal. 91%
- On-Demand Expansion Fluorescence and Photoacoustic Microscopy (ExFLPAM) 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.