In response to Li et al.: Linker histones function in Drosophila embryogenesis
Carbonell, A.; Henn, L.; Perez-Roldan, J.; Tamirisa, S.; Szabo, A.; Boros, I. M.; Azorin, F.
10.1101/2020.03.21.001529 bioRxivShow abstract
In an earlier paper (Perez-Montero et al., 2013), we reported that the embryonic linker histone of Drosophila dBigH1 was essential for early Drosophila embryogenesis since embryos homozygous for the bigH1100 mutation showed strong defects and did not survive beyond zygotic genome activation (ZGA) at cellularization. Recent results challenge these observations since null bigH1 mutations generated by CRISPR/Cas9 methodology turn out to be homozygous viable, as reported in Li et al. (2019) and here. In this regard, Li et al. described a novel mechanism by which lack of dBigH1 is compensated by the early expression of maternal dH1. Here, we confirm this observation and show that such compensatory mechanism is not activated in bigH1100 embryos.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Loss of pseudouridine synthases in the RluA family causes hypersensitive nociception in Drosophila 95%
- The effect of Drosophila attP40 background on the glomerular organization of Or47b olfactory receptor neurons 95%
- A forward genetic approach to mapping a P-element second site mutation identifies DCP2 as a novel tumor suppressor in Drosophila melanogaster 95%
Similar papers in this journal
- Different α2δ Accessory Subunits Regulate Distinctly Different Aspects of Calcium Channel Function in the Same Drosophila Neurons 93%
- An optimized protocol for assay for transposase-accessible chromatin by sequencing (ATAC-seq) library preparation from adult Drosophila melanogaster neurons 93%
- Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish 92%
Similar papers in this journal
- Nucleolar stress in Drosophila neuroblasts, a model for human ribosomopathies 94%
- The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly 94%
- Dynamic neurotransmitter specific transcription factor expression profiles during Drosophila development 93%
Similar papers in this journal
- delilah, prospero and D-Pax2 constitute a gene regulatory network essential for the development of functional proprioceptors 94%
- Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila 94%
- Expanding the Drosophila toolkit for dual control of gene expression 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.