A tissue- and organ-based cell biological atlas of obesity-related human genes and cellular pathways
Tavassoly, I.; Barbieri, V.; van Hasselt, C.; Martinez, P.; Sobie, E. A.; Hansen, J.; Azeloglu, E.; Goldfarb, J.; Sanseau, P.; Rajpal, D. K.; Iyengar, R.
Show abstract
Over the last decades, several features of obesity have been identified at behavioral, physiological, endocrine and genomic levels, and they have revealed the complexity of the disease; obesity results from a combination of genetic predisposition, endocrine disorders, and dysregulation of both food intake and energy expenditure. This complexity makes the development of new therapeutic regimens challenging and bariatric surgery is still the treatment of choice for many obese patients. Given the need for noninvasive therapeutic intervention strategies, we sought to systematically study the biological manifestations of obesity in peripheral organs. We analyzed publicly available datasets of genes, genomic determinants, and levels of obesity-related hormones in the blood, using a combination of methodologies, including graph theory and dynamical modeling, that allow for the integration of different types of datasets. The analysis revealed tissue- and organ-specific metabolic impairments and potential new drug targets. All the data are organized into a tissue/organ-based subcellular-function atlas for human obesity. The data show that the complexity of the obesity arises due to the multiplicity of subcellular processes in different peripheral organs.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Kinetic and data-driven modeling of pancreatic β-cell central carbon metabolism and insulin secretion 95%
- ADP is the dominant controller of AMP-activated protein kinase activity dynamics in skeletal muscle during exercise 93%
- A Mechanistic Modeling Framework Reveals the Key Principles Underlying Tumor Metabolism 93%
Similar papers in this journal
- Computational Analysis of Insulin-Glucagon Signalling Network: Implications of Bistability in Metabolic Homeostasis and Disease states 93%
- aiMeRA: A generic modular response analysis R package and its application to estrogen and retinoic acid receptors crosstalk 93%
- Genetic Architecture of Complex Traits and Disease Risk Predictors 93%
Similar papers in this journal
- Optimization of nutritional strategies using a mechanistic computational model in prediabetes: Application to the J-DOIT1 study data 94%
- Leveraging Dynamic Stability to Infer Regulation in Protein-Protein Interaction Networks: A Study of Infectious Vulnerability in COPD. 92%
- The amino acid composition of a protein influences its expression 92%
Similar papers in this journal
- Virtual metabolic human dynamic model for pathological analysis and therapy design for diabetes 94%
- Exploring the metabolic landscape of pancreatic ductal adenocarcinoma cells using genome-scale metabolic modeling 94%
- Kinetic modeling of leucine-mediated signaling and protein metabolism in human skeletal muscle 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.