Forensic microbial system for high-resolution object provenance
Qian, J.; Lu, Z.-x.; Mancuso, C. P.; Jhuang, H.-Y.; Barajas-Ornelas, R. d. C.; Boswell, S.; Ramirez-Guadiana, F. H.; Jones, V.; Sonti, A.; Sedlack, K.; Artzi, L.; Jung, G.; Arammash, M.; Melfi, M.; Lyon, L.; Owen, S. V.; Baym, M.; Khalil, A. S.; Silver, P. A.; Rudner, D.; Springer, M.
Show abstract
Mapping where an object has been is a fundamental challenge for human health, commerce, and food safety. Location-specific microbes offers the potential to cheaply and sensitively determine object provenance. We created a synthetic, scalable microbial spore system that identifies object provenance in under one hour at meter-scale resolution and near single spore sensitivity, and that can be safely introduced into and recovered from the environment. This system solves the key challenges in object provenance: persistence in the environment, scalability, rapid and facile decoding, and biocontainment. Our system is compatible with SHERLOCK, facilitating its implementation in a wide range of applications.
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