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Calcium-sensing receptor antagonism as a novel therapeutic for pulmonary fibrosis
2020-03-16
respiratory medicine
Title + abstract only
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BackgroundIdiopathic pulmonary fibrosis (IPF) is a disease with very poor prognosis and no curative therapies. The G protein-coupled, calcium/cation-sensing receptor (CaSR) is activated by environmental pollutants and by arginine-derived polyamines, which are thought to play a role in IPF. Whether the CaSR is involved in the pathogenesis of pulmonary fibrosis is unknown. ObjectiveTo investigate the CaSR as a novel drug target for the treatment of pulmonary fibrosis (PF). Methods and resultsCaS...
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