Molecular landscape of pelvic organ prolapse provides insights into disease etiology and clues towards putative novel treatments

2020-03-16 obstetrics and gynecology Title + abstract only

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BackgroundPelvic organ prolapse (POP) represents a major health care burden in women but its underlying pathophysiological mechanisms have not been elucidated. ObjectiveTo integrate the results from a large scale exome chip study with published genetic and expression data into a molecular landscape of POP. Design, setting, and participantsThe exome chip study was conducted in 526 women with POP and 960 healthy controls. To corroborate the findings, we analysed differential gene expression data...

Molecular landscape of pelvic organ prolapse provides insights into disease etiology and clues towards putative novel treatments

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