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Defining totipotency using criteria of increasing stringency

Posfai, E.; Schell, J. P.; Janiszewski, A.; Rovic, I.; Murray, A.; Bradshaw, B.; Pardon, T.; El Bakkali, M.; Talon, I.; De Geest, N.; Kumar, P.; To, S. K.; Petropoulos, S.; Jurisicova, A.; Pasque, V.; Lanner, F.; Rossant, J.

2020-03-03 cell biology Community evaluation
10.1101/2020.03.02.972893 bioRxiv
Show abstract

Totipotency is the ability of a single cell to give rise to all the differentiated cells that build the conceptus, yet how to capture this property in vitro remains incompletely understood. Defining totipotency relies upon a variety of assays of variable stringency. Here we describe criteria to define totipotency. We illustrate how distinct criteria of increasing stringency can be used to judge totipotency by evaluating candidate totipotent cell types in the mouse, including early blastomeres and expanded or extended pluripotent stem cells. Our data challenge the notion that expanded or extended pluripotent states harbor increased totipotent potential relative to conventional embryonic stem cells under in vivo conditions.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.