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Inference of naturally-acquired immunity using a self-matched negative control design
2020-03-06
epidemiology
Title + abstract only
View on medRxiv
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Host adaptive immune responses may protect against infection or disease when a pathogen is repeatedly encountered. The hazard ratio of infection or disease, given previous infection, is typically sought to estimate the strength of protective immunity. However, variation in individual exposure or susceptibility to infection may introduce frailty bias, whereby a tendency for infections to recur among individuals with greater risk confounds the causal association between previous infection and susc...
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