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microRNA signatures of perioperative myocardial injury after elective non-cardiac surgery: prospective observational cohort study

2020-02-27 cardiovascular medicine Title + abstract only
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BackgroundElevated plasma/serum troponin, indicating perioperative myocardial injury (PMI), is common after non-cardiac surgery. However, underlying mechanisms remain unclear. Acute coronary syndrome (ACS) is associated with the early appearance of circulating microRNAs, which regulate post-translational gene expression. We hypothesised that if PMI and ACS share pathophysiological mechanisms, common microRNA signatures should be evident. MethodsNested case-control study of samples obtained befo...

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