Hyper-connectivity of the striatum related to restricted and repetitive behaviors' severity in children with ASD
Dupong, I.; Di Martino, A.
Show abstract
Restricted and repetitive behaviors (RRB) are a core feature of autism spectrum disorder (ASD). But little is known about the underlying neurobiology of the disorder, preventing from having specific therapeutic targets. Based on the literature, we explored the correlates between a clinical score of RRB, using the Repetitive Behaviour Scale - Revised, and the intrinsic connectivity of seven striatal regions in a sample of 157 children with ASD. The sample was acquired from the ABIDE consortium. We found a significant correlation between the severity of our clinical scale and several cortico-striatal networks. Specifically, stronger connections were found between striatal seeds and two cortical areas, an occipital area and a frontal area in the left hemisphere. Intrinsic functional connectivity of the striatum could serve as a potential biomarker for improved detection of RRB severity.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Longitudinal alterations in fronto-striatal glutamate are associated with functioning during inhibitory control in autism spectrum disorder and obsessive compulsive disorder 96%
- Cortico-Cerebellar Neurodynamics during Social Interaction in Autism Spectrum Disorder 96%
- Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study 96%
Similar papers in this journal
- Dissecting the heterogeneous subcortical brain volume of Autism spectrum disorder (ASD) using community detection 97%
- Altered global modular organization of intrinsic functional connectivity in autism arises from atypical node-level processing 95%
- Decreased homotopic interhemispheric functional connectivity in children with autism spectrum disorder 95%
Similar papers in this journal
Similar papers in this journal
- Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits 95%
- Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing Human Connectome Project 94%
- Amygdala subdivisions exhibit aberrant whole-brain functional connectivity in relation to stress intolerance and psychotic symptoms in 22q11.2DS 94%
Similar papers in this journal
- Autism is associated with inter-individual variations of gray and white matter morphology 97%
- Transdiagnostic Neurobiology of Social Cognition and Individual Variability as Measured by Fractional Amplitude of Low-Frequency Fluctuation in Schizophrenia and Autism Spectrum Disorders 96%
- Limbic System White Matter in Children and Adolescents with ADHD: A Longitudinal Diffusion MRI Analysis 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.