Limited evolution despite years of measurable viremia in a cART-treated seronegative HIV-1 positive individual
Fryer, H. R.; Raghwani, J.; van Marle, G.; Golubchi, T.; Grove, J.; Lythgoe, K.
Show abstract
Understanding the role that antibodies play in controlling HIV-1 infection and in the dynamics that underpin the formation of the HIV-1 reservoir are important steps towards combatting this global disease. To address these gaps, we performed whole-genome, deep sequence analysis of longitudinal plasma HIV-1 samples from an individual who failed to develop detectable anti-HIV-1 antibodies for 4 years post infection. These analyses reveal limited evolution despite months of measurable viremia during treatment with cART. We used a mathematical model to simultaneously analyse the viral and evolutionary dynamics of this unique individual. We propose a role for antibodies in reducing viral infectivity and demonstrate how our data are consistent with a theory of rapid activation of latently infected cells prior to effective viral suppression. Our study supports and elucidates a recent finding that although the latent reservoir persists for years once virus is effectively suppressed, prior to suppression, viral strains within the reservoir turn over rapidly. The implications for a cure are significant.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A de novo approach to inferring within-host fitness effects during untreated HIV-1 infection 97%
- The Interferon Resistance of Transmitted HIV-1 is a Consequence of Enhanced Replicative Fitness 96%
- Healthy dynamics of CD4 T cells may drive HIV resurgence in perinatally-infected infants on antiretroviral therapy 96%
Similar papers in this journal
- Recombination smooths the time-signal disrupted by latency in within-host HIV phylogenies 96%
- Modeling cellular co-infection and reassortment of bluetongue virus in Culicoides midges 95%
- Quantifying the dynamics of viral recombination during free virus and cell-to-cell transmission in HIV-1 infection 95%
Similar papers in this journal
- Fitness estimation for viral variants in the context of cellular coinfection 96%
- HCV spread kinetics reveal varying contributions of transmission modes to infection dynamics 94%
- Human Herpes Virus 8 Oral Shedding Heterogeneity is Due to Varying Rates of Reactivation from Latency and Immune Containment 94%
Similar papers in this journal
- The relative contributions of infectious and mitotic spread to HTLV-1 persistence 96%
- Attenuation of HIV severity by slightly deleterious mutations can explain the long-term trajectory of virulence evolution. 96%
- Models of SIV rebound after treatment interruption that involve multiple reactivation events 95%
Similar papers in this journal
- Dynamically Linking Influenza Virus Infection Kinetics, Lung Injury, Inflammation, and Disease Severity 96%
- Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection 95%
- Selection for infectivity profiles in slow and fast epidemics, and the rise of SARS-CoV-2 variants 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.