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Bias Attributable to Composite Outcome
2020-02-17
epidemiology
Title + abstract only
View on medRxiv
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BackgroundLittle guidance is available on how composite outcomes should be interpreted, especially in situations of varied direction in the association across the event subtypes. I proposed an index to evaluate the bias attributable to composite outcomes (BACO) and applied it in recently published clinical trials. MethodsI defined the BACO index as the ratio between logarithms of the association measures of both a composite outcome and its most relevant component (e.g., any-cause mortality). By...
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