Single-cell transcriptomic profile reveals macrophage heterogeneity in medulloblastoma and their treatment-dependent recruitment
Dang, M. T.; Gonzalez, M.; Gaonkar, K. S.; Rathi, K. S.; Young, P.; Arif, S.; Zhai, L.; Alam, M.; Devalaraja, S.; Tsun, T.; Folkert, I.; Raman, P.; Rokita, J. L.; Martinez, D.; Taroni, J.; Shapiro, J.; Greene, C. S.; Savonen, C.; Hakonarson, H.; Curran, T.; Haldar, M.
Show abstract
The role of macrophages in medulloblastoma, the most common malignant pediatric brain tumor, is unclear. Using single-cell RNA sequencing in a mouse model of sonic hedgehog medulloblastoma and analysis of bulk RNA sequencing of human medulloblastoma, we investigated macrophage heterogeneity. Our findings reveal differential recruitment of macrophages with molecular-targeted versus radiation therapy and identify an immunosuppressive monocyte-derived macrophages following radiation treatment of mouse medulloblastoma, uncovering potential strategies for immunomodulation as adjunctive therapy.
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