Adhesivity and motility of a zoonotic spirochete: Implications in host-dependent pathogenicity
Xu, J.; Koizumi, N.; Nakamura, S.
Show abstract
Bacterial motility is crucial for many pathogenic species in the process of invasion and/or dissemination. The spirochete bacteria Leptospira spp. cause symptoms, such as hemorrhage, jaundice, and nephritis, in diverse mammals including humans. Although loss-of-motility attenuate the spirochete, the mechanism of the motility-dependent pathogenicity is unknown. Here, focusing on that Leptospira spp. swim in liquid and crawl on solid surfaces, we investigated the spirochetal dynamics on the host tissues by infecting cultured kidney cells from various species with pathogenic and nonpathogenic leptospires. We found that, in the case of the pathogenic leptospires, a larger fraction of bacteria attached to the host cells and persistently traveled long distances using the crawling mechanism. Our results associate the kinetics and kinematic features of the spirochetal pathogens with their virulence. One Sentence SummaryAdhesivity and crawling motility over host tissue surfaces are closely related to the pathogenicity of a zoonotic spirochete.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Bacterial filamentation is an in vivo mechanism for cell-to-cell spreading 94%
- Convergent within-host evolution alters key virulence factors in a Klebsiella pneumoniae clone during a large hospital outbreak 94%
- Construction of a complete set of Neisseria meningitidis defined mutants - the NeMeSys 2.0 collection - and its use for the phenotypic profiling of the genome of an important human pathogen 94%
Similar papers in this journal
Similar papers in this journal
- Functional genomics reveals strain-specific genetic requirements conferring hypoxic growth in Mycobacterium intracellulare 94%
- A Live Attenuated Vaccine Model Confers Cross-Protective Immunity Against Different Species of Leptospira spp. 94%
- STING mediates immune responses in the closest living relatives of animals 94%
Similar papers in this journal
- Comparative phylogenomic analysis reveals evolutionary genomic changes and novel toxin families in endophytic Liberibacter pathogens 94%
- Organoid-based in vitro system and reporter for the study of Cryptosporidium parvum sexual reproduction 92%
- An atypical F-actin capping protein modulates cytoskeleton behaviors crucial to colonization of Trichomonas vaginalis 92%
Similar papers in this journal
- Revisiting oxygen toxicity: evolution and adaptation to superoxide in a SOD-deficient bacterial pathogen 95%
- A new class of protein sensor links spirochete pleomorphism, persistence, and chemotaxis 94%
- Outer membrane tube formation by Francisella novicida involves extensive envelope modifications and is linked with type VI secretion and alterations to the host phagosomal membrane 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.