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Integrated single cell analysis of human lung fibrosis resolves cellular origins of predictive protein signatures in body fluids
2020-01-27
respiratory medicine
Title + abstract only
View on medRxiv
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Single cell genomics enables characterization of disease specific cell states, while improvements in mass spectrometry workflows bring the clinical use of body fluid proteomics within reach. The correspondence of cell state changes in diseased organs to peripheral protein signatures is currently unknown. Here, we leverage single cell RNA-seq and proteomic analysis of large pulmonary fibrosis patient cohorts to identify disease specific changes on the cellular level and their corresponding reflec...
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