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Modulation of white matter bundle connectivity in the presence of axonal truncation pathologies

Smith, R. E.; Calamante, F.; Gajamange, S.; Kolbe, S.; Connelly, A.

2020-01-15 neuroscience
10.1101/2020.01.14.903559 bioRxiv
Show abstract

Endpoint-to-endpoint fibre bundle connectivity estimated using spherical deconvolution & streamlines tractography in diffusion MRI may be excessive in the presence of pathologies that involve truncation of axons within the white matter. Here we propose a simple modification to an existing method that directly quantifies and corrects for this over-estimation.

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