Aberrant synaptic release underlies sleep/wake transition deficits in a mouse Vamp2 mutant
Banks, G. T.; Guillaumin, M. C. C.; Heise, I.; Lau, P.; Yin, M.; Bourbia, N.; Aguilar, C.; Bowl, M. R.; Esapa, C.; Brown, L. A.; Hasan, S.; Tagliatti, E.; Nocholson, E.; Bains, R. S.; Wells, S.; Vyazovskiy, V. V.; Volynski, K.; Peirson, S. N.; Nolan, P. M.
Show abstract
Sleep-wake transitions are modulated through extensive subcortical networks although the precise roles of their individual components remain elusive. Using forward genetics and in vivo electrophysiology, we identified a recessive mouse mutant line characterised by a reduced propensity to transition between all sleep states while a profound loss in total REM sleep time was evident. The causative mutation, an Ile102Asn substitution in VAMP2, was associated with substantial synaptic changes while in vitro electrophysiological investigations with fluorescence imaging revealed a diminished probability of vesicular release in mutants. We conclude that the synaptic efficiency of the entire subcortical brain network determines the likelihood that an animal transitions from one vigilance state to the next.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- EphA7 Isoforms Differentially Regulate Cortical Dendrite Development 92%
- Impaired trigeminal control of ingestive behavior in the Prrxl1- / - mouse is associated with a lemniscal-biased orosensory deafferentation 92%
- GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior 92%
Similar papers in this journal
- Presynaptic Rac1 in the hippocampus selectively regulates working memory 94%
- Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndrome 94%
- KIF2C regulates synaptic plasticity and cognition by mediating dynamic microtubule invasion of dendritic spines 94%
Similar papers in this journal
- Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism 92%
- A simple and reliable method for claustrum localization across age in mice 92%
- Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down's syndrome mouse model 91%
Similar papers in this journal
- A Novel Role for Phospholamban in the Thalamic Reticular Nucleus 95%
- Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation 93%
- Mutations affecting the N-terminal domains of SHANK3 point to different pathomechanisms in neurodevelopmental disorders. 93%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.