An RNA degradation complex required for silencing of Polycomb target genes
Zhou, H.; Shipkovenska, G.; Kalocsay, M.; Zhang, J.; Luo, Z.; Moazed, D.
Show abstract
Polycomb Repressive Complex (PRC) 1 and 2 are histone-modifying and chromatin-binding complexes that are required for silencing of developmental regulatory genes and genes that control cellular proliferation. Their gene silencing functions are thought to involve chromatin compaction and condensate formation but whether other mechanisms contribute to silencing is unknown. Here we show that the rixosome, a conserved RNA degradation complex with roles in ribosomal RNA processing and heterochromatic RNA degradation in fission yeast, associates with human PRC complexes, is recruited to promoters of Polycomb target genes in differentiated cell lines and embryonic stem cells, and is required for efficient silencing of Polycomb target genes. These findings reveal an unanticipated role for RNA degradation in Polycomb-mediated silencing.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state 96%
- ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes 96%
- Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay 96%
Similar papers in this journal
Similar papers in this journal
- MeCP2 Interacts with the Super Elongation Complex to Regulate Transcription 96%
- Identification and characterization of BEND2 as a novel and key regulator of meiosis during mouse spermatogenesis 96%
- Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch 96%
Similar papers in this journal
- SETDB1 Fuels the Lung Cancer Phenotype by Modulating Epigenome, 3D Genome Organization and Chromatin Mechanical Properties 97%
- DNA elements tether canonical Polycomb Repressive Complex 1 to human genes 96%
- Distinct structural and functional heterochromatin partitioning of lamin B1 and B2 revealed using genome-wide Nicking Enzyme Epitope targeted DNA sequencing. 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.