Peripheral nerve resident macrophages are microglia-like cells with tissue-specific programming
Wang, P. L.; Yim, A. K.; Kim, K.; Avey, D.; Czepielewski, R. S.; Colonna, M.; Milbrandt, J.; Randolph, G. J.
Show abstract
Whereas microglia are recognized as fundamental players in central nervous system (CNS) development and function, much less is known about macrophages of the peripheral nervous system (PNS). Here we show that self-maintaining PNS macrophages share unique features with CNS microglia. By comparing gene expression across neural and conventional tissue-resident macrophages, we identified transcripts that were shared among neural resident macrophages as well as selectively enriched in PNS macrophages. Remarkably, PNS macrophages constitutively expressed genes previously identified to be upregulated by activated microglia during aging or neurodegeneration. Several microglial activation-associated and PNS macrophage-enriched genes were also expressed in spinal cord microglia at steady state. While PNS macrophages arose from both embryonic and hematopoietic precursors, their expression of activation-associated genes did not differ by ontogeny. Collectively, these data uncover shared and unique features between neural resident macrophages and emphasize the role of nerve environment for shaping PNS macrophage identity.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Single-Cell Multiome Sequencing Clarifies Enteric Glial Cell Diversity and Identifies an Intraganglionic Population Poised for Neurogenesis 95%
- The immune landscape of murine skeletal muscle regeneration and aging 95%
- Microglial phagocytosis of single dying oligodendrocytes is mediated by CX3CR1 but not MERTK 94%
Similar papers in this journal
- Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave 94%
- Single cell transcriptomics reveals functionally specialized vascular endothelium in brain 94%
- Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signalling pathway. 94%
Similar papers in this journal
- Predictive framework of macrophage activation 95%
- The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair 94%
- Origin and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages. 94%
Similar papers in this journal
Similar papers in this journal
- Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment 94%
- Molecular pathology of acute spinal cord injury in middle-aged mice 94%
- Single Cell Profiling of CD45+ Spinal Cord Cells Reveals Microglial and B Cell Heterogeneity and Crosstalk Following Spinal Cord Injury 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.