A role for the locus coeruleus in the modulation of feeding
Sciolino, N. R.; Mazzone, C. M.; Plummer, N. W.; Evsyukova, I.; Amin, J.; Smith, K. G.; McGee, C. A.; Fry, S. A.; Yang, C. X.; Powell, J. M.; Bruchas, M. R.; Kravitz, A. V.; Cushman, J. D.; Krashes, M. J.; Cui, G.; Jensen, P.
Show abstract
Recent data suggest that LC-NE neurons play a role in fear-induced suppression of feeding, but their endogenous activity in naturally behaving animals has not been explored. We found that endogenous activity of LC-NE neurons was enhanced during food approach and suppressed during food consumption, and that these food-evoked LC-NE responses were attenuated in sated mice. Interestingly, visual-evoked LC-NE activity was also attenuated in sated mice, demonstrating that internal satiety state modulates LC-NE encoding of multiple behavioral states. We also found that food intake could be attenuated by brief or longer durations of LC-NE activation. Lastly, we demonstrated that activation of LC neurons suppresses feeding and enhances avoidance and anxiety-like responding through a projection to the lateral hypothalamus. Collectively, our data suggest that LC-NE neurons modulate feeding by integrating both external cues (e.g., anxiogenic environmental cues) and internal drives (e.g., nutritional state).
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