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Drug-Induced Decreased Urine Output Predicts Pda Closure In Preterm Neonates
2019-12-19
pediatrics
Title + abstract only
View on medRxiv
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ObjectiveProstaglandin inhibitors (PGI) are used to treat patent ductus arteriosus (PDA) of prematurity. PGIs often cause decrease in urine output (UO), the mechanism of which is like that of PDA closure. We hypothesized that PGI-induced decrease in UO predicts PDA closure. DesignProspective, cohort SettingLevel III NICU MethodsWe prospectively enrolled 40 preterm neonates ([≤]34 weeks gestation) with clinical and/or echocardiographic hemodynamically significant PDA (hsPDA), being treated ...
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