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Compromised intestinal barrier underlies gut microbiota dysbiosis of intestinal diseases

2019-11-29 gastroenterology Title + abstract only
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BackgroundDespite recent efforts, a single factor underlying the gut microbiota dysbiosis in intestinal diseases is not identified. We hypothesized that compromised intestinal barrier (CIB) could lead to increased host-derived contents including human cells in the gut, change its physio-metabolic properties, and globally alter gut microbiota and their metabolic capacities. ResultsConsistently, we found human DNA contents (HDCs), calculated as the percentage of metagenomic sequencing reads mappe...

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