Estimating the causal effect of adiposity on carpal tunnel syndrome: a Mendelian randomization study
Daghlas, I.; Varady, N.
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IntroductionWe investigated whether higher body mass index (BMI) may causally increase risk of carpal tunnel syndrome using Mendelian randomization (MR). MethodsThe exposure included genetic instruments comprising independent variants associated with BMI (n=322,154). Associations of these variants with CTS were obtained from a genome-wide association study conducted in UK Biobank (UKB; 12,312 cases/389,344 controls) with replication in the FinnGen cohort (4,505 cases/86,854 controls). Causal effects were estimated using inverse-variance weighted regression, and sensitivity analyses probed robustness of results. ResultsA 1-standard deviation (4.7kg/m2) increase in genetically instrumented BMI increased the odds of CTS in UKB (OR 1.73, 95% CI 1.48-2.02, P=2.68x10-12; 16.8 additional cases per 1000 person-years [95% CI 11.0-23.5]). This effect was consistent in the replication sample and across sensitivity analyses. DiscussionThese data support a causal effect of higher BMI on susceptibility to CTS. Clinical investigations of weight loss for treatment of CTS may be warranted.
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