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Predictive approaches to heterogeneous treatment effects: a systematic review

2019-11-02 epidemiology Title + abstract only
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BackgroundRecent evidence suggests that there is often substantial variation in the benefits and harms across a trial population. We aimed to identify regression modeling approaches that assess heterogeneity of treatment effect within a randomized clinical trial. MethodsWe performed a literature review using a broad search strategy, complemented by suggestions of a technical expert panel. ResultsThe approaches are classified into 3 categories: 1) Risk-based methods (11 papers) use only prognos...

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