Association between CCR5-Δ32 homozygosity and mortality in 37,650 participants from three U.S.-based cohorts
Jiang, X.; Huang, H.; Grodstein, F.; Kraft, P.
Show abstract
An analysis of 409,693 UK Biobank participants recently published in Nature Medicine identified a relative 21% increase in all-cause mortality among participants who were homozygous for the {Delta}32 deletion in the C-C motif chemokine receptor 5 gene (CCR5).1 This is a timely and potentially cautionary result in light of He Jiankuis controversial germline editing of CCR5 to induce mutations that putatively mimic the effects of {Delta}32, which is known to reduce the risk of HIV infection. To provide additional evidence on the association between the {Delta}32 deletion and mortality and assess its generalizability, we present results from three large-scale population-based US cohorts: the Nurses Health Study (NHS),2 the NHSII and the Health Professional Follow-Up Study (HPFS).3
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