Prevalence and clinical importance of titin truncating variants in adults without known congestive heart failure

2019-08-20 cardiovascular medicine Title + abstract only

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BackgroundCross-sectional studies of various forms of dilated cardiomyopathy have noted a truncating mutation in the gene encoding titin ( TTNtv) in 7-30% of patients, but the clinical importance of identifying a TTNtv in an asymptomatic adult is largely unknown. In contrast to cross-sectional studies, prospective cohort studies allow for unbiased estimates of the disease risks associated with a genotype exposure. ObjectivesTo determine the prevalence of cardiac imaging abnormalities and risk o...

Prevalence and clinical importance of titin truncating variants in adults without known congestive heart failure

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