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Early detection of molecular disease progression by whole-genome circulating tumor DNA in advanced solid tumors
2019-07-24
oncology
Title + abstract only
View on medRxiv
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PurposeTreatment response assessment for patients with advanced solid tumors is complex and existing methods of assessment require greater precision for early disease assessment. Current guidelines rely on imaging, which has limitations such as the long time required before treatment effectiveness can be determined. Serial changes in whole-genome (WG) circulating tumor DNA (ctDNA) were used to detect disease progression early in the treatment course. Methods97 patients with advanced cancer were...
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