A pleiotropic chemoreceptor facilitates the coupling of pheromonal signal perception and production
Zelle, K.; Vernier, C.; Liang, X.; Halloran, S.; Millar, J.; Ben-Shahar, Y.
Show abstract
Optimal mating decisions depend on stable signaling systems because any independent changes in either the signal or its perception could carry a fitness cost. However, since the perception and production of specific mating signals are often mediated by different tissues and cell types, the genetic and cellular mechanisms that drive and maintain their coupling on the evolutionary and physiological timescales remain unknown for most animal species. Here, we show that in Drosophila melanogaster, sensory perception and synthesis of an inhibitory mating pheromone is regulated by the action of Gr8a, a member of the Gustatory receptor gene family. Particularly, Gr8a acts as a pheromone chemoreceptor in the sensory system of males and females, and, independently regulates pheromone synthesis in the male fat body and oenocytes. These data provide a relatively simple molecular explanation for how genetic coupling allows for the robust and stable flow of social information at the population level.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- fruitless tunes functional flexibility of courtship circuitry during development 96%
- The neuropeptide sulfakinin is a peripheral regulator of insect behavioral switch between mating and foraging 96%
- Sex-peptide targets distinct higher order processing neurons in the brain to induce the female post-mating response 96%
Similar papers in this journal
- CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression 95%
- Choline Transporter regulates olfactory habituation via a neuronal triad of excitatory, inhibitory and mushroom body neurons 94%
- Ets Transcription Factor Pointed Controls Germline Survival In Drosophila 94%
Similar papers in this journal
- Octopaminergic/tyraminergic Tdc2 neurons regulate biased sperm usage in female Drosophila melanogaster 95%
- Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in C. elegans 94%
- Imaginal disc growth factors are Drosophila Chitinase-like Proteins with roles in morphogenesis and CO2 response 94%
Similar papers in this journal
- Activity and stress during a critical period regulate olfactory sensory neuron differentiation 96%
- Modulation of fatty acid elongation sustains sexually dimorphic hydrocarbons and female attractiveness in Blattella germanica (L.) 95%
- DAF-16/FoxO and DAF-12/VDR control cellular plasticity both cell-autonomously and via interorgan signaling 93%
Similar papers in this journal
- Contributions of the conserved insect carbon dioxide receptor subunits to odor detection 96%
- Coordination Among Multiple Receptor Tyrosine Kinase Signals Controls Drosophila Developmental Timing and Body Size 95%
- Affinity Requirements For Control Of Synaptic Targeting And Neuronal Cell Survival By Heterophilic IgSF Cell Adhesion Molecules 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.