A novel polymorphism in nitric oxide synthase interacting protein (NOSIP) modulates nitric oxide and mortality in Human Sepsis
Mukherjee, R.; Singh, D. K.; Patra, R.; Barman, P. K.; Prusty, B. K.; Thatoi, P.; Tripathy, R.; Das, B. K.; Ravindran, B.
Show abstract
Nitric oxide, synthesised by three isoforms of Nitric Oxide synthases viz., nNOS by neurons, eNOS by endothelial cells and iNOS by phagocytes, performs a wide variety of biological functions in neurons, vascular endothelial cells and immune cells. Interaction between inducible nitric oxide synthase (iNOS) and Nitric oxide synthase interacting protein (NOSIP) was observed both in human monocytes and mouse macrophages and in cell free systems by biophysical methods. A novel mutation in nitric oxide synthase interacting protein (NOSIP) determined NO levels produced by human monocytes and was associated with disease severity in Sepsis patients. The study reveals NOSIP as an important regulator of inflammation by virtue of its ability to influence nitric oxide production both in mice and in humans and opens up novel avenues for therapeutic strategies against acute inflammation. While the influence of this novel NOSIP polymorphism in cardio-vascular and neuronal functions could be a subject of future investigations, its role in determining disease severity and mortality of the ongoing Covid 19 pandemic will be of immediate relevance.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Plasma gradient of soluble urokinase-type plasminogen activator receptor is linked to pathogenic plasma proteome and immune transcriptome and stratifies outcomes in severe COVID-19 95%
- Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis. 95%
- The inhibition of Macrophage Migration Inhibitory Factor by ISO-1 attenuates trauma-induced multi organ dysfunction in rats 95%
Similar papers in this journal
- Novel prognostic determinants of COVID-19-related mortality: a pilot study on severely-ill patients in Russia 95%
- Clustering ICU patients with sepsis based on the patterns of their circulating biomarkers: a secondary analysis of the CAPTAIN prospective multicenter cohort study 94%
- Effects of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients 94%
Similar papers in this journal
Similar papers in this journal
- Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients 96%
- SARS-CoV-2 immune complex triggers human monocyte necroptosis 92%
- Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain. 92%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.