Antiviral Sulfonated Polymersomes Inhibit Corona-, Influenza-, and Alphavirus
McCabe, S.; Zhu, R.; Setia, R. Y.; Brown, J. C.; Pan, Z.; Zhu, X.; Xu, X.; Kaya, B.; Wong, I.; Koropouli, F.; Londono, P. S.; Mok, K. Y.; Kugathasan, R.; Rifaie-Graham, O.; Torraca, V.; Galao, R. P.; Barclay, W. S.; Najer, A.
Show abstract
A broad-spectrum antiviral is required to enable rapid intervention against current, newly emerging and mutating viruses. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus (IAV), Sindbis virus (SINV) and chikungunya virus (CHIKV) all engage negatively charged moieties on host cells, such as heparan sulfate (HS) and sialic acid, to facilitate attachment for entry and infection. We designed HS-mimetic nanoparticles in the form of polymer vesicles (polymersomes) by blending membrane-forming and sulfonated copolymers. These biocompatible polymersomes successfully inhibited host cell infection of HS-dependent SARS-CoV-2 and HS-independent IAV in vitro with sub-nanomolar potency. Multivalent interaction of several virus ligands with a single polymersome as quantified by fluorescence correlation spectroscopy likely contributes to their potency. The sulfonated polymersomes also functioned in vivo as demonstrated by a reduction in the spread of SINV, an alphavirus model for CHIKV, in zebrafish embryos, which led to a significantly increased survival. Hence, our polymersomes could form the basis for an urgently required multifunctional broad-spectrum antiviral nanomedicine.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Nicotinamide-loaded Peptoid Nanotubes for Energy Regeneration in Acute Brain Injury 94%
- Bottlebrush polyethylene glycol nanocarriers translocate across human airway epithelium via molecular architecture enhanced endocytosis 94%
- Controlling wireframe DNA origami nuclease degradation with minor groove binders 93%
Similar papers in this journal
- Pancreatic Tumor Eradication via Selective PIN1 Inhibition in Cancer Associated Fibroblasts and T Lymphocytes Engagement 94%
- In Vivo Metabolic Tagging and Targeting of Circulating Red Blood Cells 93%
- Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds 93%
Similar papers in this journal
- Hydroxychloroquine-functionalized Ionizable Lipids Mitigate Inflammatory Responses in mRNA Therapeutics 95%
- Hybrid Adipocyte-Derived Exosome Nano Platform for Potent Chemo-Phototherapy in Targeted Hepatocellular Carcinoma 94%
- Nanochirality-programmed Type-I photosensitizer enables deep-tumor photodynamic therapy by reducing extracellular-matrix adhesion 94%
Similar papers in this journal
- Immune-informed mucin hydrogels evade fibrotic foreign body response in vivo 94%
- An Engineered Living Material with pro-angiogenic activity inducible by near-infrared light 94%
- Optimizing Angiopep-2 Density on Polymeric Nanoparticles for Enhanced Blood-Brain Barrier Penetration and Glioblastoma Targeting: Insights from In Vitro and In Vivo Experiments 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.