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CARE-MVLM: Counterfactual Abstention and Region-Grounded Evidence in Mammography Vision-Language Models

Qu, B.; Liu, W.; Murrow, M.; Burger, M.; Guo, X.; Vaidya, M. S.; Rose, S. L.; Kantarcioglu, M.; Malin, B. A.; Yin, Z.

2026-09-25 radiology and imaging
10.64898/2026.09.23.26363835 medRxiv
Show abstract

Mammography interpretation requires tying each finding to supporting evidence and withholding judgment when that evidence is unavailable. Vision-language models are increasingly used for image-based medical question answering, yet existing benchmarks suggest that they struggle to jointly support accurate answers, evidence grounding, and appropriate abstention. We propose CARE-MVLM, built on Qwen2.5-VL-7B-Instruct, to address this gap through separate modules for answer prediction, answer-conditioned evidence generation, and answerability selection. On 7,358 triplets curated from CBIS-DDSM, MIAS, and VinDr-Mammo, CARE-MVLM substantially improves lesion-sensitive selective behavior over same VLM backbone baselines and exhibits markedly stronger lesion-sensitive abstention than GPT-5.6 and Gemini-3.5-flash while attaining the highest joint answer, grounding, and abstention reliability in the comparison.

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