The hydrocup: a hollow electrospun scaffold for in vivo hydrogel-laden cell delivery
Boaventura Gomes, D.; Zonderland, J.; Vermeulen, S.; Rezzola, S.; Henriques Ferreira Lourenco, A.; van Beurden, D.; Venema, J.; Liu, H.; Peters, M.; Emans, P.; Bouvy, N.; Rademakers, T.; Wieringa, P.; Camarero-Espinosa, S.; Moroni, L.
Show abstract
For regenerative medicine applications, transplanted cells are difficult to retain in a specific place to maximize the localized release of cytokines, which can positively modulate immune responses, angiogenesis and tissue regeneration. Here, we developed a hollow electrospun (ESP) scaffold with one open and one closed end to enclose a hydrogel laden with human mesenchymal stem cells (hMSCs); we termed this combination the hydrocup. hMSCs remained viable for 28 days in vitro and released functional cytokines similar to hMSCs in transplanted but non-enclosed hydrogels. The hydrocups remained intact and fixed in place for 6 weeks after subcutaneous implantation in rats, demonstrating in vivo compatibility. These results demonstrate that the hydrocup is the first, to our knowledge, cell-laden hydrogel delivery scaffold. This innovation could be developed for a wide variety of cell-based cytokine secretion or drug-laden hydrogel applications.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A versatile microfluidic extrusion-based hydrogel platform for self-organization and long-term maintenance of engineered 3D lymphatic endothelium 96%
- Genipin-Crosslinked, Silane-Anchored 3D Tumor-Stroma Microtissues for High-Content On-Chip Drug Testing 95%
- Geometrical Designs in Volumetric Bioprinting to Study Cellular Behaviors in Engineered Constructs 95%
Similar papers in this journal
- An Engineered Living Material with pro-angiogenic activity inducible by near-infrared light 96%
- A Synthetic Dynamic PVA Photoresin for Fast Volumetric Bioprinting of Functional Ultrasoft Hydrogel Constructs 95%
- Yield Stress and Creep Control Depot Formation and Persistence of Injectable Hydrogels Following Subcutaneous Administration 95%
Similar papers in this journal
- Reprogrammable 4D Tissue Engineering Hydrogel Scaffold via Reversible Ion Printing 97%
- Bioactive Hydrogel Microcapsules for Guiding Stem Cell Fate Decisions by Release and Reloading of Growth Factors 96%
- Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries 95%
Similar papers in this journal
- Spatial control of viscoelasticity in phototunable hyaluronic acid hydrogels 96%
- Reinforcement of Fibrillar Collagen Hydrogels with Bioorthogonal Covalent Crosslinks 96%
- Impact of Molecular Dynamics of Polyrotaxanes on Chondrocytes in Double Network Supramolecular Hydrogels under Physiological Thermomechanical Stimulation 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.