Peer-guided movie neurofeedback to facilitate recovery in opioid use disorder
Kronberg, G.; McClain, N. E.; Boros, M.; Santhapuram, S.; Drury, K. R.; Hennings, A. C.; Hasson, U.; Alia-Klein, N.; Norman, K. A.; Goldstein, R. Z.
Show abstract
Real-time fMRI neurofeedback can modify clinically relevant brain states, but transferring brain dynamics between peers has not been tested, particularly in addiction, where social learning is central to recovery. Here we introduce peer-guided movie neurofeedback (PG-MovieNF), which trains participants to align their brain activity with treatment-related dynamics derived from peers further along in recovery viewing the same movie. Using longitudinal fMRI data from individuals with opioid use disorder watching Trainspotting before and after 8 weeks of adjunctive treatment, we derived a multivariate treatment-predictive signal in dorsolateral and dorsomedial prefrontal cortex. An independent cohort then received real PG-MovieNF or yoked sham feedback during the same film. Real feedback increased alignment with the peer-derived target signal, reduced craving and improved affective ratings. Target alignment was coupled to shared orbitofrontal cortex dynamics during real feedback and predicted craving reduction. Together, these findings establish proof of concept for PG-MovieNF to enhance addiction recovery.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Comparing neuromodulation targets to reduce cigarette craving and withdrawal: A randomized clinical trial 92%
- Nicotine dependence (trait) and acute nicotinic stimulation (state) modulate attention but not cognitive control: converging fMRI evidence from Go-Nogo and Flanker tasks 92%
- Cortical dopamine reduces the impact of motivational biases governing automated behaviour 91%
Similar papers in this journal
- Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks 90%
- First-in-human low-intensity focused ultrasound targeting striatal circuits in schizophrenia: feasibility, safety, and effects on hallucinations and striatal-temporal functional connectivity 90%
- TMS-induced modulation of brain networks and its associations to rTMS treatment for depression: a concurrent fMRI-EEG-TMS study 89%
Similar papers in this journal
- Dynamic Functional Hyperconnectivity after Psilocybin Intake is Primarily Associated with Oceanic Boundlessness 91%
- Clinical and functional connectivity outcomes of 5-Hz repeated transcranial magnetic stimulation as an add-on treatment in cocaine use disorder: a double-blind randomized controlled trial 90%
- Computationally-informed insights into anhedonia and treatment by κ -opioid receptor antagonism 90%
Similar papers in this journal
- Predictive Patterns of Antidepressant Response from Pre-Treatment Reward Processing using Functional MRI and Deep Learning: Key Results from the EMBARC Randomized Clinical Trial 91%
- Human extinction learning is accelerated by an angiotensin antagonist via ventromedial prefrontal cortex and its connections with basolateral amygdala 90%
- Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction 90%
Similar papers in this journal
- Clinical Response to Neurofeedback in Major Depression Relates to Subtypes of Whole-Brain Activation Patterns During Training 92%
- Angiotensin blockade enhances motivational reward learning via enhancing ventral striatal prediction error and frontostriatal communication 92%
- Longitudinal evolution of the transdiagnostic prodrome to severe mental disorders: a dynamic temporal network analysis informed by natural language processing and electronic health records 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.