Real-World Effectiveness of Maternal RSVpreF Vaccination and Durability of Infant Protection
Xu, H.; Aparicio-Llorente, C.; Wats, A.; Araujo, B. L.; Ganem, J. M.; Oliva, I. O.; Shapiro, E. D.; Brodsky, N. N.; Aronson, P. L.; Grubaugh, N. D.; Lucas, C. L.; Niccolai, L. M.; Warren, J. L.; Kennedy-Shaffer, L.; Pitzer, V. E.; Weinberger, D. M.; Oliveira, C. R.
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In this test-negative study, the effectiveness of the maternal RSVpreF vaccine among infants <6 months was 73.9% against medically attended respiratory syncytial virus (RSV) infection and 86.3% against RSV-associated hospitalization. Maternal RSVpreF and nirsevimab had comparable initial effectiveness, but effectiveness of RSVpreF waned approximately 1.7 times more rapidly.
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