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Congenital syphilis outcomes by penicillin dosing intervals among women with late latent or latent of unknown duration syphilis during pregnancy in eight U.S. jurisdictions: 2018-2023

Martinson, E.; Lewis, E. L.; Newton, S.; Carlson, J. M.; Miele, K.; O'Callaghan, K. P.; Anderson, B.; Falzarano, T.; Levin, T. R.; Jayroe, M.; Johnson, C. M.; Longcore, N. D.; Berryhill, A.; Willabus, T.; Woodworth, K. R.; Tong, V. T.

2026-09-07 epidemiology
10.64898/2026.09.03.26361028 medRxiv
Show abstract

Pregnant women with late latent or latent of unknown duration syphilis are recommended to receive three doses of benzathine penicillin G each 9 or fewer days apart; data on interval variations are limited. We found no significant difference in risk of congenital syphilis between 9-day and 6-8 day dosing intervals.

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