Evaluating the autoantibody reactome in giant cell arteritis
Porteous, M.; Maughan, R. T.; Sorensen, L.; Zulcinski, M.; Aslam, A.; Mackie, S. L.; Pericleous, C.; Tomlinson, J.; Luqmani, R. A.; Pickering, M. C.; Morgan, A. W.; Peters, J. E.
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Objective: To determine whether autoantibodies are present in giant cell arteritis (GCA) using a high-dimensional autoantibody array. Methods: Serum was collected from patients with GCA (n=20), other related vascular inflammatory diseases (Takayasu arteritis n=12, IgG4-RD n=5, Behcet's disease n=6), SLE (n=5) and healthy controls (n=12). Autoantibodies to 15,312 protein targets were measured using the GeneCopeia OmicsArray proteomic antigen microarray panel. Results: Differential abundance analysis revealed no autoantibodies significantly elevated in GCA or other related vascular inflammatory diseases. In contrast, the SLE group showed a strong and promiscuous autoantibody response, with 175 significantly associated autoantibodies (Benjamini-Hochberg-adjusted P <0.05). Conclusions: No autoantibodies were significantly elevated in GCA. We identified known and novel autoantibodies in SLE.
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