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Simple synthesis and functionalisation of α-hydroxyglycine-containing peptide fragments

Solanke, P. R.; Sarkar, D.; Saha, P. C.; Taylor, M. T.

2026-06-02 biochemistry
10.64898/2026.05.29.728772 bioRxiv
Show abstract

We report here a method for the chemical synthesis of Fmocprotected -hydroxyglyine (-OH-Gly) dipeptides. Our method features operational simplicity and is compatible with protecting groups for peptide synthesis. Utility is then demonstrated through substitution at the -OH-Gly position to yield myriad non-natural amino acid-containing dipeptide fragments.

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