Back

Strengthening specialized capacity in Greek public services through the co-development and implementation of psychotherapeutic protocols for child and adolescent mental health conditions

Triantafyllou, K.; Koumoula, A.; Konialis, E.; Papoulias, P.; Moustaka, D.; Karagiorga, V. E.; Schafer, J. L.; Simioni, A.; Marchionatti, L. E.; Schuster, K.; Emanuele, J.; Casella, C. B.; Bernstein, H.; Breidenstine, A.; Woodward, E. C.; Tsoukala, C.; Aggeli, K.; Kaklamani, G.; Balikou, P.; Varveri, C.; Karyotaki, E.; Koulouvaris, T.; Scarmeas, N.; Burke, S.; Szatmari, P.; Cuijpers, P.; Rapee, R.; Vlachos, C.; Parousi, S.; Vasilopoulou, F.; Serdari, A.; Athanasopoulou, L.; Zilikis, N.; Dafoulis, V.; Basta, M.; Kotsis, K.; Papanikolaou, K.; Koplewicz, H.; Salum, G. A.

2026-05-01 psychiatry and clinical psychology
10.64898/2026.04.30.26352158 medRxiv
Show abstract

IntroductionDespite evidence supporting child and adolescent cognitive behavioural therapy (CBT) globally, interventions remain largely unavailable within public systems. This gap requires implementation models integrating development, training, and scalability research within real-world settings and changes in management structures. Here we developed and implemented manualised psychotherapeutic protocols through a national capacity-building initiative in Greece. MethodsWe designed a structured implementation pathway conducted through the Child and Adolescent Mental Health Initiative (CAMHI), a public-private partnership involving clinical and academic institutions across Greece: (1) pre-implementation research through national reviews and national surveys of health professionals; (2) co-development and iterative pilot implementation of evidence-based interventions through supervised practice within the National Health System; and (3) dissemination research supporting scalability and institutionalisation within public structures. ResultsPre-implementation research identified gaps in the availability of clinical protocols in Greek services; a survey of 120 psychologists and psychiatrists indicated the need for psychotherapeutic training. Three evidence-based protocols were co-developed: CBT for anxiety (6-12 years), CBT for depression (12-17 years), and behavioural parent training (BPT) for disruptive behaviour (4-14 years). During a three-stage pilot, 45 clinicians delivered interventions to 140 cases (anxiety n=52; depression n=25; BPT n=63); 117 (83{middle dot}5%) completed treatment. Significant symptom reductions were observed for anxiety (d=-2{middle dot}92; RCADS-25), depression (d=-1{middle dot}79, RCADS-25), and disruptive behaviour (d=-2{middle dot}3, SNAP-IV), with 63%, 38% and 44% showing reliable improvement at the treatment endpoint. A train-the-trainer model is under implementation for national scale-up. Institutionalisation includes integration into child and adolescent psychiatry curricula. Sustainability safeguards were established through Law 5015/2023, with the Ministry of Health assuming operations by 2027. DiscussionPilot results demonstrate the feasibility of evidence-based psychotherapeutic interventions embedded within real-world child and adolescent services in Greece. Integrated implementation approaches provide a viable pathway for developing, refining, and scaling clinical manuals within public health provision.

Matching journals

The top 8 journals account for 50% of the predicted probability mass.

1
Psychiatry Research
35 papers in training set
Top 0.1%
12.0%
2
Frontiers in Psychiatry
83 papers in training set
Top 0.4%
8.2%
3
European Psychiatry
10 papers in training set
Top 0.1%
6.2%
4
Psychological Medicine
74 papers in training set
Top 0.3%
6.1%
5
BMJ Mental Health
15 papers in training set
Top 0.1%
6.1%
6
BMC Psychiatry
22 papers in training set
Top 0.1%
4.7%
7
The British Journal of Psychiatry
21 papers in training set
Top 0.2%
4.7%
8
BJPsych Open
25 papers in training set
Top 0.1%
4.2%
50% of probability mass above
9
Social Psychiatry and Psychiatric Epidemiology
11 papers in training set
Top 0.1%
4.2%
10
PLOS ONE
4510 papers in training set
Top 39%
3.6%
11
Journal of Affective Disorders
81 papers in training set
Top 0.6%
3.5%
12
European Child & Adolescent Psychiatry
14 papers in training set
Top 0.1%
3.5%
13
BMC Medicine
163 papers in training set
Top 2%
2.7%
14
Acta Psychiatrica Scandinavica
10 papers in training set
Top 0.1%
2.4%
15
BMC Health Services Research
42 papers in training set
Top 0.9%
2.3%
16
Epidemiology and Psychiatric Sciences
10 papers in training set
Top 0.1%
2.0%
17
PLOS Medicine
98 papers in training set
Top 2%
1.7%
18
Journal of Psychiatric Research
28 papers in training set
Top 0.5%
1.4%
19
eClinicalMedicine
55 papers in training set
Top 0.8%
1.4%
20
Frontiers in Public Health
140 papers in training set
Top 6%
1.3%
21
Schizophrenia Bulletin
29 papers in training set
Top 0.5%
1.3%
22
Acta Neuropsychiatrica
12 papers in training set
Top 0.6%
1.3%
23
Journal of Medical Internet Research
85 papers in training set
Top 4%
0.9%
24
BMJ Open
554 papers in training set
Top 12%
0.8%
25
JMIR Research Protocols
18 papers in training set
Top 2%
0.7%
26
Translational Psychiatry
219 papers in training set
Top 4%
0.7%
27
Molecular Psychiatry
242 papers in training set
Top 4%
0.6%
28
Autism Research
32 papers in training set
Top 0.5%
0.6%