Bridging Genetics and Precision Medicine in Parkinson's Disease through GP2
Atterling Brolin, K.; Lange, L. M.; Navarro-Jones, E.; Jasaityte, S.; Ye Beh, Y.; Fang, Z.-H.; Iwaki, H.; Jones, L.; Klein, C.; Kleinz, T.; Leonard, H. L.; Mata, I.; Noyce, A.; Okubadejo, N. U.; Saffie Awad, P.; Screven, L.; Tan, A. H.; Toffoli, M.; Vitale, D.; Singleton, A.; Blauwendraat, C.; Nalls, M. A.; Morris, H.; the Global Parkinson's Genetics Program (GP2),
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In the Global Parkinson's Genetics Program (GP2) we aim to advance precision medicine by integrating large-scale clinico-genetic data from diverse populations worldwide. We investigated potentially trial-eligible carriers of pathogenic and high-risk GBA1 and LRRK2 variants and conducted a global precision-medicine survey across GP2 sites. Among 65,509 individuals with Parkinson's disease, we identified 9,019 (13.8%) potentially trial-eligible genetic variant carriers, including 6,789 GBA1, 2,084 LRRK2, and 146 dual GBA1-LRRK2 carriers. Individuals were distributed across multiple global regions, many of which currently lack active gene-targeted trials, highlighting a global disparity between relevant variant carriers and the availability of disease modifying treatment trials. GP2's unified framework supports equitable recruitment for gene-targeted therapeutic studies and helps address critical gaps in Parkinson's disease genetics and future therapeutic development.
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