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Expanding TheCellMap.org to visualize a genome-scale genetic interaction network for a human cell line

Horecka, I.; Usaj, M.; Masinas, M. P. D.; Ward, H. N.; Zhang, X.; Hassan, A. Z.; Billmann, M.; Rost, H.; Myers, C. L.; Costanzo, M.; Andrews, B. J.; Boone, C.

2026-03-18 systems biology
10.64898/2026.03.16.712129 bioRxiv
Show abstract

Genetic interaction networks map functional connections between genes and their corresponding pathways and complexes. We previously developed TheCellMap.org as a central repository for storing and analyzing quantitative genetic interaction data produced by genome-scale Synthetic Genetic Array (SGA) analysis in the budding yeast, Saccharomyces cerevisiae. We have expanded TheCellMap.org to include ~89,000 quantitative genetic interactions identified from genome-scale CRISPR-based analysis of ~4 million human gene pairs in the haploid cell line, HAP1. TheCellMap.org enables users to readily access, visualize and explore human HAP1 genetic interactions, as well as to extract and reorganize sub-networks, applying data-driven network layouts in an intuitive and interactive manner.

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