Child poverty and declining measles, mumps and rubella (MMR) vaccination in England, 2015 to 2024. A longitudinal ecological study at local area level

ObjectiveTo assess the contribution of changing child poverty rates to trends in measles, mumps and rubella (MMR) vaccination. DesignLongitudinal area-level analysis using within-between models to assess the association of increases in child poverty within-areas on MMR vaccination Setting148 upper-tier local authorities in England from 2015 and 2024. ParticipantsChildren aged 5 years or younger eligible for MMR vaccination in England between 2015 and 2024. 6,468,620 children aged 24 months were included in the study and 6,907,640 aged 5 years. ExposuresChild poverty rates for each upper-tier local authority, measured as the percentage of children aged 0 to 15 living in households below 60% of Organisation for Economic Co-operation and Development (OECD) median, before housing costs. Outcome MeasuresMMR 1st and 2nd dose uptake rates by 24 months 5 years of age respectively, at upper-tier local authority. ResultsOver the study period, MMR 1st dose fell by 4.0 percentage-points (%) (range: -20.8 to 7.7) and MMR 2nd dose by 4.9% (range: -23.4 to 10.1) while child poverty rose by 5.6% (range: 0.2 to 13.9) on average. A 1 percentage-point (%) increase in child poverty was associated with a 0.17% [95%CI: -0.29; -0.06] fall in MMR 1st dose rates and a 0.26% [95%CI: -0.42; -0.10] fall in MMR 2nd dose rates. ConclusionRising child poverty rates have contributed to a decrease in MMR vaccination in children in England. Action to reduce child poverty is needed to improve childhood vaccination uptake alongside policies and interventions specific to vaccination and infectious disease prevention. Summary boxO_ST_ABSWhat is already known on this topicC_ST_ABSInequalities in childhood vaccination uptake in England are stark and have widened, especially for MMR vaccination. Child poverty in England has increased and is associated with rising inequalities in multiple domains of childrens health but impacts on inequalities in vaccination uptake are unclear. What this study addsA 1 percentage-point increase in child poverty was associated with a 0.17 percentage point fall in uptake of MMR1 and a 0.26 percentage point fall in MMR2 between 2015 and 2024. Reducing child poverty is likely to increase vaccine uptake and reduce the burden of vaccine preventable diseases in England.