Back
#1
22.3%
Top 7%
11.9%
Top 5%
6.4%
Top 4%
5.0%
Top 63%
4.2%
Top 5%
3.9%
Top 15%
3.1%
Top 1%
2.8%
Top 4%
2.8%
Top 90%
2.8%
Top 3%
1.9%
Top 2%
1.9%
Top 2%
1.9%
Top 6%
1.6%
Top 3%
1.5%
Top 5%
1.2%
Top 4%
1.0%
Top 8%
1.0%
Top 6%
1.0%
Top 7%
1.0%
Top 2%
1.0%
Top 3%
1.0%
Top 17%
0.7%
Top 10%
0.7%
Top 12%
0.7%
Top 5%
0.7%
Top 20%
0.7%
Top 25%
0.5%
Prediction of incident coronary artery disease in individuals with zero coronary artery calcium using a novel multi-ancestry, label-free polygenic risk score framework
2026-03-04
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
BackgroundA coronary artery calcium (CAC) score of 0 is widely considered to indicate low short- to intermediate-term risk for coronary artery disease (CAD) and is frequently used to defer lipid-lowering therapy. However, a subset of individuals with CAC=0 still experience events, highlighting residual risk not captured by imaging alone. Polygenic risk scores (PRS) quantify lifelong inherited susceptibility, but conventional approaches rely on predefined ancestry labels despite human genetic div...
Predicted journal destinations
1
Circulation: Genomic and Precision Medicine
30 training papers
2
Nature Communications
483 training papers
3
Journal of the American Heart Association
92 training papers
4
The American Journal of Human Genetics
77 training papers
5
Scientific Reports
701 training papers
6
Nature Genetics
72 training papers
7
eLife
262 training papers
8
Human Molecular Genetics
28 training papers
9
Genome Medicine
56 training papers
10
PLOS ONE
1737 training papers
11
Human Genetics and Genomics Advances
39 training papers
12
PLOS Genetics
39 training papers
13
Cell Genomics
34 training papers
14
Genetics in Medicine
57 training papers
15
Stroke
29 training papers
16
European Journal of Human Genetics
25 training papers
17
Genes
21 training papers
18
Alzheimer's & Dementia
84 training papers
19
Circulation
37 training papers
20
Frontiers in Genetics
32 training papers
21
Bioinformatics
24 training papers
22
Diabetologia
23 training papers
23
Nature Medicine
88 training papers
24
Nature
58 training papers
25
International Journal of Epidemiology
65 training papers
26
Science Advances
52 training papers
27
Proceedings of the National Academy of Sciences
100 training papers
28
npj Digital Medicine
85 training papers