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Constructing a Literature-Derived Database for Benchmarking Polygenic Risk Score Construction Methods with Spectral Ranking Inferences

2026-03-03 genetic and genomic medicine Title + abstract only
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Polygenic risk scores (PRSs) have emerged as a valuable tool for genetic risk prediction and stratification in human diseases. Over the past decade, extensive methodological efforts have focused on improving the predictive power of PRS, leading to the development of numerous methods for PRS construction. Benchmarking these various methods thus becomes an essential task that is crucial for guiding future PRS applications. While studies have benchmarked subsets of these methods on specific phenoty...

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