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Population Pharmacokinetic Modeling of Intravenous Topiramate in Patients with Epilepsy and Migraine
2026-03-02
pharmacology and therapeutics
Title + abstract only
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Topiramate (TPM) is approved for seizures and migraine prophylaxis and is used off-label for several neuropsychiatric conditions. The available dosage forms, including tablets and sprinkle capsules, are unsuitable for patients who may be unable to take medicine orally. The resulting potential treatment interruptions could have untoward consequences and underscores the importance of developing a parenteral formulation. In this study, we developed a population pharmacokinetic model of a novel, int...
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