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Exercise Reverses the Sedentary Cardiac Phenotype in Obesity: A Systematic Review and Meta-Analysis of Hemodynamic, Structural, and Functional Adaptations

2026-02-28 cardiovascular medicine Title + abstract only
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Background and AimSedentary lifestyle and obesity are considered to be significant risk factors that create a pathway for the appearance of the sedentary cardiac phenotype consisting of cardiac atrophy, myocardial stiffening, and altered haemodynamics. Although exercise training has the potential to reverse this detrimental process, the literature data on the magnitude of improvements and the certainty of evidence are inconsistent. This systematic review and meta-analysis aimed to evaluate the ...

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