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Constructing and analyzing a synthetic life course cohort based on pooling two data sources: A case study of early adulthood depression symptomatology and late-life cognition
2026-02-27
epidemiology
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BackgroundSynthetic cohorts created by combining two cohorts can be useful when no single data set includes both the exposure and outcome data of interest. We estimate the effects of depression in early adulthood on later-life memory outcome using two nationally representative cohorts separately and in a synthetic sample. MethodsWe used the National Longitudinal Study of Youth 1979 (NLSY; N=5,747) and the Health and Retirement Study (HRS; N=6,846) and a synthetic cohort combining exposure data ...
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