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Genetic susceptibility versus fibrosis progression in North Indian MASLD: distinct roles of APOC3 and PNPLA3 in a candidate gene study
2026-02-27
gastroenterology
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Background and AimMASLD affects 30-38% of Indian adults, yet the contribution of genetic risk variants to disease susceptibility and fibrosis progression remains poorly characterised. We investigated the association of 12 candidate SNPs with MASLD susceptibility and fibrosis severity in North Indian patients, benchmarking allele frequencies against IndiGenomes and global populations. MethodsSixty-nine MASLD patients (75.4% male; median BMI 29.8 kg/m{superscript 2}) from a tertiary care liver cl...
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