Early DNA methylation at the NGFI-A binding site of the NR3C1 1F promoter predicts cognitive functions at age five: evidence from the Parents as Teachers intervention in the ZEPPELIN study
Gardini, E. S.; Neuhauser, A.; Schaub, S.; Kalkusch, I.; Rodcharoen, P.; Ehlert, U.; Lanfranchi, A.; Turecki, G.; Klaver, P.
Show abstract
BackgroundThe present study examines the link between DNA methylation at the nerve growth factor-induced protein A (NGFI-A) binding domain of the NR3C1 1F promoter and later cognitive functions in children from families living in disadvantaged psychosocial conditions. MethodsParticipants were 132 children who took part in a Swiss Parents as Teachers (PAT) randomized controlled trial (72 in the intervention group, 60 in the control group). DNA methylation was quantified from saliva samples collected at age three using sodium bisulfite next-generation sequencing (NGS). Cognitive functions were assessed at age five using the SON-R 2.5-7 Intelligence Test. Results(a) DNA methylation at age three predicted lower IQ at age five through increased concentration problems; (b) participation in the three-year PAT program predicted lower methylation levels at the end of the intervention; and (c) early life stressors predicted lower IQ through increased methylation and concentration problems with descriptively stronger effects in the control group. ConclusionsThese findings demonstrate a link between early DNA methylation at the NGFI-A binding site of the NR3C1 1F promoter and later cognitive functions in children and highlight the role of early life stressors and the PAT intervention in shaping these associations.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Maternal characteristics and their relation to early mother-child interaction and cognitive development in toddlers 95%
- The association of child maltreatment and systemic inflammation in adulthood: A systematic review 93%
- A cross-national study of factors associated with women’s perinatal mental health and wellbeing during the COVID-19 pandemic 93%
Similar papers in this journal
- The Impact of Premature Birth and Low Birth Weight on Motor, Visual, and Cognitive Skills and Mental Health in Adolescence: A Systematic Review and Meta-analysis 95%
- Internalizing Problems Before and During the COVID-19 Pandemic in Dutch Children and Adolescents with and without Pre-Existing Mental Health Problems 94%
- The Bidirectional Relationship Between Head Injuries and Conduct Problems: Longitudinal Modelling of a Population-Based Birth Cohort Study 94%
Similar papers in this journal
- “Puberty age gap”: New method of assessing pubertal timing and its association with mental health problems 92%
- An Examination of Sustained Versus Transient Distressing Psychotic-Like Experiences Using Adolescent Brain Cognitive Development℠ Study Data 91%
- Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings 90%
Similar papers in this journal
Similar papers in this journal
- Systematic Review and Meta-Analysis of the Effect of Adverse Childhood Experiences (ACEs) on Brain-Derived Neurotrophic Factor (BDNF) Levels 92%
- Targeted bisulfite sequencing: A novel tool for the assessment of DNA methylation with high sensitivity and increased coverage 90%
- Relationship between constitutive and acute gene regulation, and physiological and behavioral responses, mediated by the neuropeptide PACAP 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.