Triglyceride-rich lipoproteins, low-density lipoproteins, and risk of abdominal aortic aneurysm

2026-02-24 cardiovascular medicine Title + abstract only

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BackgroundThe comparative roles of triglyceride-rich lipoproteins (TRLs) and low-density lipoproteins (LDLs) in abdominal aortic aneurysm (AAA) pathogenesis are unclear. ObjectivesTo evaluate the putative causal role of TRLs in AAA, quantify the relative effect on AAA risk ("aneurysmogenicity") of TRL vs LDL particles, and prioritize lipid-lowering drug targets for AAA prevention and treatment. MethodsWe performed summary-level and individual-level Mendelian randomization (MR) analyses. Geneti...

Triglyceride-rich lipoproteins, low-density lipoproteins, and risk of abdominal aortic aneurysm

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